A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis

A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis

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here Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis.Its structure was established by spectroscopic analysis, including NMR and HR-MS (High Resolution Mass Spectrometry).Sanggenon X contained three O-bridged rings, where the oxygenated bridgeheads were all quaternary carbons.Chemical methylation was carried out to deduce the linkages of the three O-bridges.The absolute configuration was determined by calculating the ECD (Electronic Circular Dichroism) using the TDDFT (Time-Dependent Density Functional Theory) method.

Sanggenon X showed significant antioxidant activity against Fe2+-Cys-induced lipid peroxidation in rat liver microsomes, and was as effective click here as the positive control, curcumin.